The case against a randomized trial of unruptured brain arteriovenous malformations: misinterpretation of a flawed study.
نویسندگان
چکیده
Nicholas C. Bambakidis, Kevin M. Cockroft, Joshua A. Hirsch, E. Sander Connolly, Sepideh Malformations: Misinterpretation of a Flawed Study The Case Against A Randomized Trial of Unruptured Brain Arteriovenous Print ISSN: 0039-2499. Online ISSN: 1524-4628 Copyright © 2014 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Stroke doi: 10.1161/STROKEAHA.114.006519 2014;45:2808-2810; originally published online July 31, 2014; Stroke. http://stroke.ahajournals.org/content/45/9/2808 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
A randomized trial of unruptured brain arteriovenous malformations (ARUBA).
Despite almost a century of efforts in the treatment of brain arteriovenous malformations (BAVMs) no clinical trial has yet been performed to demonstrate the benefits of intervention versus conservative (medical) management for those not yet bled. Only insufficient information on the natural history of unbled BAVMs exists to certify that intervention is needed and that such intervention produce...
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Cerebral arteriovenous malformations (AVMs) are rare vascular lesions detected at an annual incidence of ≈1 in 100 000. The natural history of unruptured AVMs is more benign than ruptured ones, primarily because of their lower hemorrhage risk. The only currently available strategy for AVM management that provides durable relief from the risk of hemorrhage is complete obliteration of the nidus. ...
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The efficacy of mechanical thrombectomy with stent retrievers for emergent large vessel occlusion has been proved by randomized trials. Mechanical thrombectomy is increasingly being adopted in Japan since stent retrievers were first approved in 2014. An urgent clinical task is to offer structured systems of care to provide this treatment in a timely fashion to all patients with emergent large v...
متن کاملRisk Reduction of Cerebral Stroke After Stereotactic Radiosurgery for Small Unruptured Brain Arteriovenous Malformations.
BACKGROUND AND PURPOSE A Randomized Trial of Unruptured Brain Arteriovenous Malformations (ARUBA) indicated the superiority of medical management in reducing the risks for strokes and other neurological deficits over observation alone. The aim of our study was to verify the rationale for stereotactic radiosurgery (SRS) for small unruptured arteriovenous malformation. METHODS A retrospective r...
متن کاملRadiosurgery for Cerebral Arteriovenous Malformations in A Randomized Trial of Unruptured Brain Arteriovenous Malformations (ARUBA)-Eligible Patients: A Multicenter Study.
BACKGROUND AND PURPOSE The benefit of intervention for patients with unruptured cerebral arteriovenous malformations (AVMs) was challenged by results demonstrating superior clinical outcomes with conservative management from A Randomized Trial of Unruptured Brain AVMs (ARUBA). The aim of this multicenter, retrospective cohort study is to analyze the outcomes of stereotactic radiosurgery for ARU...
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عنوان ژورنال:
- Stroke
دوره 45 9 شماره
صفحات -
تاریخ انتشار 2014